CIRS is also known as ‘chronic inflammatory response syndrome’. CIRS is a term that was created by Ritchie Shoemaker, MD (11) out of the necessity to define the pathology of biotoxin and mold-related illness. CIRS is based upon a series of inflammatory responses to biotoxin exposure, such as mold exposure from water-damaged buildings (11, 12).
Summary & Contents The cell danger response (CDR) is a cellular-initiated threat involving the signaling of extracellular nucleotides such as ATP and ADP Extracellular ATP is a potent purinergic signaling molecule involved in inflammation Mast cell activation disorder (MCAS or MCAD) involves the degranulation of mast cells and release of numerous chemical messengers and inflammatory
Summary & Contents The extracellular matrix is comprised of electrolytes, glycosaminoglycans, polysaccharides, collagen & proteins The extracellular matrix is essential for how cells function through the regulation of the cell’s life cycle, cytoskeletal signaling, growth factor maturation and utilization, cytokine and immune cell recruitment and modulation Toxins like mercury, mold, aluminum, glyphosate and drugs like fluoroquinolones can