Mast Cell Activation Disorder & The Cell Danger Response

Summary & Contents The cell danger response (CDR) is a cellular-initiated threat involving the signaling of extracellular nucleotides such as ATP and ADP Extracellular ATP is a potent purinergic signaling molecule involved in inflammation Mast cell activation disorder (MCAS or MCAD) involves the degranulation of mast cells and release of numerous chemical messengers and inflammatory

The Extracellular Matrix: Key To Unravelling Chronic Disease?

Summary & Contents The extracellular matrix is comprised of electrolytes, glycosaminoglycans, polysaccharides, collagen & proteins The extracellular matrix is essential for how cells function through the regulation of the cell’s life cycle, cytoskeletal signaling, growth factor maturation and utilization, cytokine and immune cell recruitment and modulation Toxins like mercury, mold, aluminum, glyphosate and drugs like fluoroquinolones can

RCCX: A Link to Complex Illness & Why Its Important

Individuals with joint hypermobility often present with complex symptom presentations, including: MCAD (mast cell activation disorders), POTS (postural orthostatic tachycardia syndrome), PTSD (post traumatic stress disorder), autoimmune diseases and dysautonomia, endometriosis, ovarian cysts, ME/CFS, mental and behavioral conditions and emotional and sensory processing disorders. Variability of the RCCX cluster provides a very appealing and viable

Hyper Joint Mobility, EDS, Collagen, Histamine & CIRS: Implications

Ehlers danlos syndrome, commonly referred to as EDS is a vastly under-diagnosed connective tissue disorder in the human population. EDS is classified as having at least 13 different subtypes, and there is much confusion as to the relationship with other connective tissue disorders. The implications for EDS are vast, and extend into areas of immunology, endocrinology, neurology, cardiology, mitochondrial

High Histamine Rollercoaster: Implications of This Potent Neuro-Immune Modulator

Histamine is a powerful molecule. When it is activated, it has numerous physiological effects through its various histamine receptors. Understanding the various roles that histamine occupies, confers new insights into the implications for dietary, immunological, gastro-intestinal, cardiovascular, endocrinological, neurological, and inflammatory mechanisms. 4 histamine receptors have been identified, and each exert different effects. Histamine is released by