Estrogen is a necessary cofactor in the biosynthesis of phosphatidylcholine. Women with low estrogen may be at risk for phosphatidylcholine deficiency. Choline & Estrogen: Menopausal Links In summary: In females, estrogen is a cofactor in the function of PEMT, a gene that biosynthesizes the phospholipid, phosphatidylcholine Due to lower estrogen, post menopausal women may have
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