Introduction to Genetic Testing. Are genetic tests really as important as we are led to believe? Direct –to- consumer genetic testing has entered the market, and with it has come a fury of misconceptions and misunderstandings, but also the opportunity to learn inherited strengths and weaknesses. I also Discuss:

•Many of the myths and truths regarding genetic testing, such as the problem of treating the part (a single genetic SNP) instead of treating the whole (the person with the genetic defects)

 

•The role of DNA versus the functionality of RNA

 

•What a mutation is, and some of the Environmental factors that cause genetic mutations

 

•The essentiality of epigenetics (diet, toxicity and lifestyle) on gene expression

Methylation plays a vital role in how your body functions. In fact, numerous health issues today involve various problems in how well we methylate or don’t. However it isn’t only about the MTHFR gene, or for that matter any single gene or enzyme

In videos #2 and 3, we present the methylation cycles (methionine & folate cycles) in an animated and easy to follow fashion.

•Additionally, we highlight each of the major gene/enzymes in the methylation cycles. These include: MTHFR, MAT, AHCY, BHMT, MTR, MTRR, CBS, SUOX, COMT, MAO-A, NOS, SHMT, GAMT, PEMT, SOD, DHFR, GAD1.

•We discuss the importance of glutathione and the role of homocysteine.

•We discuss the connection methylation has on the brain, via neurotransmitter synthesis and degradation

•We discuss the importance of methylation on cardiovascular health, via the formation of nitric oxide & homocysteine.

The integration and practice of 21st century, evidence-based clinical nutrition is an essential paradigm for understanding how to overcome the multi-factorial nature of 21st century health challenges.

The practice of 21st century, evidence-based clinical nutrition necessitates the utilization and application of a myriad of components such as: genetic test analysis, in-depth biochemical test analysis, application of advanced nutritional therapies, and a smooth and efficient client management system.

Through the practice of 21st century, evidence-based clinical nutrition, practitioners teach their clients biological adaptation, which is critical for thriving and surviving despite the myriad of 21st century stressors.

This first chapter will focus on the identification of the 3 Primary Client Types: •Mood, Behavior, Mental Health •Inflammation

○Neuro-immune

○Gastro-intestinal

○Neuro-endocrine

○Vascular

•Detoxification   As well as: •Symptomology of the 3 Client Types, as well their corresponding functional lab testing. •Key components of the clinical investigative process. •Introduction and integration of functional blood chemistry analysis.

As a clinician it is critical to understand the specific and desired biochemical action of key nutrient groups.

This section will focus in-depth on the 10 key nutrient groups, which are an integral part of nutrient therapies for each of the 3 client types. You will learn what these key nutrients do, how to apply them based upon clinical evidence and certain lab test results, and in what amounts.

When working with advanced nutrient therapies, it is essential for the clinician to monitor the effects of recommended nutrients. Throwing a bunch of supplements at someone without monitoring their effects is irresponsible and potentially harmful.

You will learn key layering and titration techniques in order to get behind the “control switches” of your nutrient therapies.

The 10 nutrient groups discussed are: • Vitamin B-6/P5P • Vitamin B-12 • Folates • Lecithin/Phospholipids • Niacinamide/Niacin • Vitamin B-1 • Zinc/Copper • Calcium/Magnesium • Glutathione/NAC • Vitamins C & E

The concerns of abnormal estrogen metabolism have profound implications for huge sets of clinical presentations, and diseases such as: cancer, endometriosis, PCOS, uterine fibroids, autoimmune disease and others.

We now have the ability through the use of advances in clinical practice and technologies to employ an in-depth, evidence-based investigative process into the genetics, epigenetics and biochemistry of estrogen and sex hormone metabolism.

These new screening processes enable a more complete and in-depth method of looking at the problems associated with estrogen and sex hormone metabolism, as well as serving as a basis for advanced nutritional and biochemical-specific nutrient therapies.

This first section will elucidate on:

•Phase 1 and phase 2 metabolism and detoxification as it relates to estrogen

•Examples of estrogen-related RNA concentrations in various tissues

•Literature that discusses associated conditions with two major estrogen genes: CYP1B1 and CYP3a4

•Importance of individualized therapies

The clinical implementation of genetic testing holds tremendous potential for the advancement of functional medicine and nutritionally-oriented practices. Screening for the major genes of estrogen metabolism enables clinicians to quickly identify inherited strengths and weaknesses, helping to form an impression of pathway analysis. Understanding the corresponding biochemistry of each estrogen-related gene enables clinicians to have a more complete and evidence-based means of therapeutic intervention

This second section will teach:

•Use of the Metabolic Healing Nutrigenomics Report: Estrogen Metabolism Genetics •In-depth discussion of risk alleles for specific SNPs •Corresponding biochemistry diagram for each gene set •Use of the Precision Analytical DUTCH sex hormone test •Dissection of each biochemical pathway •Environmental, epigenetic and nutritional influences upon these pathways •Estrogen Methylation, Glucuronidation, Semi-Quinones formation & Detoxification •Copper, Histamine & Related-concerns