Gilbert’s syndrome is a condition involving a defect in a phase 2 glucuronidation gene known as UGT1a1. The result of this causes elevations in the levels of unconjugated bilirubin. The current scientific consensus is that Gilbert’s is a relatively benign condition. I disagree with that contention. I believe that UGT1A1 genetic polymorphisms are prone towards
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CIRS is also known as ‘chronic inflammatory response syndrome’. CIRS is a term that was created by Ritchie Shoemaker, MD (11) out of the necessity to define the pathology of biotoxin and mold-related illness. CIRS is based upon a series of inflammatory responses to biotoxin exposure, such as mold exposure from water-damaged buildings (11, 12).
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The origins of autoimmune thyroid disease should be appropriately viewed from the context of immunological dysregulation, set forth by a myriad number of genetic and epigenetic factors. This view should seek to investigate the metabolic significances of thyroid physiology, with its highly oxidative environment, as well as its propensities towards heightened danger signaling and innate
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The label “adrenal fatigue” has been debated and deconstructed, endlessly for decades. Adrenal fatigue, or adrenal burnout is a term used by alternative healthcare practitioners as an attempt to make sense of an array of symptoms pertaining to fatigue, exhaustion, and everything that is associated with those symptoms. Practitioners utilize various cortisol hormone tests, as
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RCCX is a copy number variation (CNV) gene cluster located on chromosome 6. Variations of the RCCX genotype leads to an increased susceptibility to numerous diseases. Significant research links together one of the RCCX genes, C4b with autism, associated cell danger signaling, and problems related to neuronal, synaptic pruning. Last year I wrote an article
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One of the major complications of CIRS and mold illness is a type of sinus infection known as marcons. Marcons stands for Multiple Antibiotic Resistant Coagulase Negative Staphylococci. Marcons is a type of staph bacteria that produces a biofilm, making it difficult to eradicate. in addition to resulting in sinusitis symptoms, marcons is believed to complicate
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BCL-2 is a key protein inside cells that functions as a type of control switch for cell-programmed death, known as apoptosis. Significantly, cancer cells are locked in a malignant state of cell division, where apoptosis genes are down-regulated or switched off. Over-expression of BCL-2 in cancer cells is associated with the inability of cancer cells
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The medicinal properties of fungi are well established. The primary immune-activating constituents include various polysaccharides, including beta glucans, mannans and lectins. The effects of these polysaccharides have far-reaching possibilities for various aspects of the human immune system, including those relating to innate, complement immunity. Polysaccharides & The Complement Immune System The complement immune system is
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It is now becoming clear that attempting to test for and correct Vitamin D deficiencies is far more involved than simply looking at levels of 25-hydroxyvitamin D and using supplemental Vitamin D3. That approach fails to recognize the fact that many factors will mediate how 25-hydroxyvitamin D is converted into the active secosteroid hormone Calcitriol
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I have previously reported on the issue of glutamate excitotoxicity. This article is a brief exploration of GAD1, an important gene that is involved in the conversion of the excitatory neurotransmitter glutamate into the inhibitory neurotransmitter GABA. The issue of glutamate toxicity is well understood. In essence, glutamate can result in cell programmed death when
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