Defining The RCCX Phenotype
The RCCX gene cluster on chromosome 6 is one of the most complex regions of the human genome, and one that is likely a major player in chronic disease susceptibility.…
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Gilbert’s Syndrome, UGT1A1: More Than Meets The Eye
Gilbert’s syndrome is a condition involving a defect in a phase 2 glucuronidation gene known as UGT1a1. The result of this causes elevations in the levels of unconjugated bilirubin. The…
CIRS Testing (chronic inflammatory response syndrome) & Why It May Be Critical
CIRS is also known as ‘chronic inflammatory response syndrome’. CIRS is a term that was created by Ritchie Shoemaker, MD (11) out of the necessity to define the pathology of…
Autoimmune Thyroid, Danger Signaling & Innate Immune Activation
The origins of autoimmune thyroid disease should be appropriately viewed from the context of immunological dysregulation, set forth by a myriad number of genetic and epigenetic factors. This view should…
CYP21a2, RCCX & Adrenal Function: A Completely Different Perspective
The label “adrenal fatigue” has been debated and deconstructed, endlessly for decades. Adrenal fatigue, or adrenal burnout is a term used by alternative healthcare practitioners as an attempt to make…
Autism, RCCX, C4b Deficiency & Synaptic Pruning
RCCX is a copy number variation (CNV) gene cluster located on chromosome 6. Variations of the RCCX genotype leads to an increased susceptibility to numerous diseases. Significant research links together…
Optimizing the Nasal Biome: Marcons, Mold & Probiotics
One of the major complications of CIRS and mold illness is a type of sinus infection known as marcons. Marcons stands for Multiple Antibiotic Resistant Coagulase Negative Staphylococci. Marcons is a…
BCL-2, Mitochondria & Cancer: Natural Inhibitors
BCL-2 is a key protein inside cells that functions as a type of control switch for cell-programmed death, known as apoptosis. Significantly, cancer cells are locked in a malignant state…
Polysaccharides, Mushrooms & The Complement Immune System
The medicinal properties of fungi are well established. The primary immune-activating constituents include various polysaccharides, including beta glucans, mannans and lectins. The effects of these polysaccharides have far-reaching possibilities for…
5 Factors That Inhibit Your Vitamin D Receptor (VDR)
It is now becoming clear that attempting to test for and correct Vitamin D deficiencies is far more involved than simply looking at levels of 25-hydroxyvitamin D and using supplemental…