BCL-2 is a key protein inside cells that functions as a type of control switch for cell-programmed death, known as apoptosis. Significantly, cancer cells are locked in a malignant state of cell division, where apoptosis genes are down-regulated or switched off. Over-expression of BCL-2 in cancer cells is associated with the inability of cancer cells
The medicinal properties of fungi are well established. The primary immune-activating constituents include various polysaccharides, including beta glucans, mannans and lectins. The effects of these polysaccharides have far-reaching possibilities for various aspects of the human immune system, including those relating to innate, complement immunity. Polysaccharides & The Complement Immune System The complement immune system is
It is now becoming clear that attempting to test for and correct Vitamin D deficiencies is far more involved than simply looking at levels of 25-hydroxyvitamin D and using supplemental Vitamin D3. That approach fails to recognize the fact that many factors will mediate how 25-hydroxyvitamin D is converted into the active secosteroid hormone Calcitriol
I have previously reported on the issue of glutamate excitotoxicity. This article is a brief exploration of GAD1, an important gene that is involved in the conversion of the excitatory neurotransmitter glutamate into the inhibitory neurotransmitter GABA. The issue of glutamate toxicity is well understood. In essence, glutamate can result in cell programmed death when
Lactobacillus reuteri is perhaps one of the most intriguing and significant beneficial microorganisms in the human gut lining. It has been studied as a key modulator of the intestinal immune system, and has even been studied as a regulator of the TH-helper cell response, which is a key component of the autoimmune process. The therapeutic
In our fast paced, technologically-maximized society, I stand off to the side and ask some serious questions: • Why is the health of our planet and the human race so compromised? • Why are chronic diseases now epidemic? • What are the major causes of chronic disease? • Why has the western medical system failed
The overuse of prescription insulin is a major problem among type 2 diabetics. Why? Because type 2 diabetes is best defined at the cell level as “insulin resistance”. The function of the insulin receptor is in a state of compromise. Among type 2 diabetics. the use of prescription insulin can have deleterious consequences. It is
Summary & Contents The cell danger response (CDR) is a cellular-initiated threat involving the signaling of extracellular nucleotides such as ATP and ADP Extracellular ATP is a potent purinergic signaling molecule involved in inflammation Mast cell activation disorder (MCAS or MCAD) involves the degranulation of mast cells and release of numerous chemical messengers and inflammatory
Summary & Contents The extracellular matrix is comprised of electrolytes, glycosaminoglycans, polysaccharides, collagen & proteins The extracellular matrix is essential for how cells function through the regulation of the cell’s life cycle, cytoskeletal signaling, growth factor maturation and utilization, cytokine and immune cell recruitment and modulation Toxins like mercury, mold, aluminum, glyphosate and drugs like fluoroquinolones can
Bone broth and collagen supplements are often recommended for healing purposes. While much nutritional benefit may be obtained through bone broth and collagen, there are increasing concerns regarding the toxicity of GMO feeds, the use of glyphosate-containing pesticides on crops, and the inadvertent ingestion of glyphosate through consuming bone broth and collagen supplements or foods.