NFE2L2 is the gene that codes for the NRF2 nuclear transcription factor. Nuclear transcription factors comprise a family of genes that each control the expression of numerous target genes. NRF2 is normally ubiquinated and inactive within the cytoplasm of cells. Under conditions of cellular stress, NRF2 becomes activated and mobilizes to the nucleus, where it
The APOE 4/4 genotype (often referred to in literature as “APOE homozygotes” or APOE -/-) carry a significantly increased risk of Alzheimer’s disease and cardiovascular disease. By understanding the deeper science of the APOE gene, it may be possible to procure treatment protocols and support the body where it may be lacking. Functions of the
Preeclampsia in pregnancy is defined by systolic blood pressure levels greater than 140 or diastolic pressure greater than 90. In addition to elevations in blood pressure, other common clinical findings of preeclampsia may include: proteinuria (elevated urinary protein), elevated liver enzymes, edema (fluid retention), headaches and visual disturbances. Preeclampsia can cause several pregnancy complications, including