Maladaptive Genetics: Evolutionary Mismatches, Helminthic Therapy & Complex Disease in the Modern Era

The concept of Evolutionary Mismatches was first expounded on by Ernst Mayr in the 1940’s. That is, certain inherited traits that were once advantageous have become maladaptive in a different or changed environment. The concept of Evolutionary Mismatch is central to understanding the genetic involvement with the rising tide of complex, chronic disease in the