Summary & Contents The cell danger response (CDR) is a cellular-initiated threat involving the signaling of extracellular nucleotides such as ATP and ADP Extracellular ATP is a potent purinergic signaling molecule involved in inflammation Mast cell activation disorder (MCAS or MCAD) involves the degranulation of mast cells and release of numerous chemical messengers and inflammatory
Summary & Contents The extracellular matrix is comprised of electrolytes, glycosaminoglycans, polysaccharides, collagen & proteins The extracellular matrix is essential for how cells function through the regulation of the cell’s life cycle, cytoskeletal signaling, growth factor maturation and utilization, cytokine and immune cell recruitment and modulation Toxins like mercury, mold, aluminum, glyphosate and drugs like fluoroquinolones can
Bone broth and collagen supplements are often recommended for healing purposes. While much nutritional benefit may be obtained through bone broth and collagen, there are increasing concerns regarding the toxicity of GMO feeds, the use of glyphosate-containing pesticides on crops, and the inadvertent ingestion of glyphosate through consuming bone broth and collagen supplements or foods.
Individuals with joint hypermobility often present with complex symptom presentations, including: MCAD (mast cell activation disorders), POTS (postural orthostatic tachycardia syndrome), PTSD (post traumatic stress disorder), autoimmune diseases and dysautonomia, endometriosis, ovarian cysts, ME/CFS, mental and behavioral conditions and emotional and sensory processing disorders. Variability of the RCCX cluster provides a very appealing and viable
Ehlers danlos syndrome, commonly referred to as EDS is a vastly under-diagnosed connective tissue disorder in the human population. EDS is classified as having at least 13 different subtypes, and there is much confusion as to the relationship with other connective tissue disorders. The implications for EDS are vast, and extend into areas of immunology, endocrinology, neurology, cardiology, mitochondrial
One of the myoproliferative diseases known as essential thrombocytosis (aka essential thrombocythemia, and essential thrombocythaemia) is a potentially fatal condition that involves the overproduction of blood platelets. New clinical evidence has emerged that shows an assortment of herbal medicines are effective at significantly reducing blood platelets, and with negligible toxicity. What Is Essential Thrombocytosis? Also known
Research on PCOS (polycystic ovarian syndrome) has been focusing on mechanisms to control insulin resistance, androgen excess and hormonal signaling problems that are characteristic presentations leading to symptoms and complications. Is it possible that isomer forms of the vitamin Inositol are efficacious in PCOS? Research has recently been published demonstrating the effects of myo-inositol (as opposed
Summary 78% of people with autoimmune disease are women The rate of Hashimoto’s thyroiditis is 7X more likely to occur in women than men Lower estrogen increases CD8 lymphocytes, which is central to activation of TH1 inflammatory immunity and viral defense Evidence from mice suggests Estradiol medication can reactivate HSV-1 (herpes simplex-1) EBV (epstein barr virus)