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The PON1 genotype Q192R, risk allele ‘C’ is now considered a ‘high impact’ genotype that significantly increases cardiovascular disease risk. This article is an attempt to underscore the importance of PON1 and its associated antioxidant functions in the prevention of heart disease. We will cover some major literature on PON1, including genetics, the influence of
Type 2 diabetes is a multi-factorial condition characterized by chronically elevated blood glucose. While a wide variety of different dietary strategies have been trialed, studied and evaluated, there is a greater need to develop more targeted and individualized dietary treatments, tailored to each patient. Metabolic Type Nutrition is a type of evaluation of dietary and
Nattokinase is a fibrinolytic enzyme derived from Japanese Natto, a fermented soy food. Accumulating research identifies nattokinase as a potent anti-fibrinolytic and anti-thrombotic agent, serving as a potential treatment for: cardiovascular disease, hypertension, myocarditis, chronic kidney disease and beyond. A 2022 study involving 1,062 heart disease patients in China found high doses of nattokinase significantly
Emerging scientific research is leading to breakthroughs in the understanding of albumin, the most abundant serum protein. This research links together many of albumin’s diverse roles in human physiology and disease states. This includes albumin’s critical roles in: redox and antioxidant biology, acute inflammation, hemostasis, osmotic fluid regulation, and cellular energy metabolism. This article is
NFE2L2 is the gene that codes for the NRF2 nuclear transcription factor. Nuclear transcription factors comprise a family of genes that each control the expression of numerous target genes. NRF2 is normally ubiquinated and inactive within the cytoplasm of cells. Under conditions of cellular stress, NRF2 becomes activated and mobilizes to the nucleus, where it
The APOE 4/4 genotype (often referred to in literature as “APOE homozygotes” or APOE -/-) carry a significantly increased risk of Alzheimer’s disease and cardiovascular disease. By understanding the deeper science of the APOE gene, it may be possible to procure treatment protocols and support the body where it may be lacking. Functions of the